Prospective comparison of circumferential and longitudinal strain in asymptomatic children with single left ventricle, single right ventricle and normal hearts

Background Ventricular dysfunction in patients with a single right ventricle (SRV) or a single left ventricle (SLV) is a known risk factor for morbidity and mortality. However, the differences in SRV and SLV function remain poorly understood, with only a few studies performed1-3. In this study, we measure the strain using cardiac MRI and perform comprehensive comparison of the global and regional strain in both the circumferential (εcc) and longitudinal (εL) dimension. Purpose: In normal subjects and asymptomatic patients with SLV and SRV after total cavopulmonary connection (TCPC), compare: 1) Global εcc and εL strain, 2) Regional circumferential and longitudinal strains at free wall (εcc-free, εL-free) and septum (εcc-sept, εL-sept), 3) εcc and εL across the ventricle from apex to base.